ESOMEPRAZOLE MAGNESIUM (AS ENTERIC COATED PELLETS) 40 mg + DOMEPERIDONE (AS SUSTAINES RELEASE PLLETS) 30 mg.
Esomeprazole Magnesium 40 mg + Domperidone Sustained Release 30 mg is a combination medicine used for the treatment of gastroesophageal reflux disease (GERD), acidity, heartburn, acid reflux, gastritis, indigestion, nausea, and bloating. Esomeprazole is a proton pump inhibitor (PPI) that effectively reduces excess stomach acid production, while Domperidone is a prokinetic agent that improves gastrointestinal motility and helps relieve nausea, vomiting, and fullness. The enteric-coated and sustained-release pellet formulation ensures better protection, controlled release, and prolonged therapeutic action.
Mechanism of Action
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Esomeprazole suppresses gastric acid secretion by inhibiting the proton pump (H+/K+ ATPase) in the stomach lining.
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Domperidone enhances gastric emptying and improves movement of the stomach and intestines, thereby reducing reflux, nausea, and bloating.
Indications
Used in the treatment and management of:
- Gastroesophageal reflux disease (GERD)
- Acid reflux and heartburn
- Gastritis
- Peptic ulcer disease
- Indigestion and bloating
- Nausea and vomiting associated with gastric disorders
- Functional dyspepsia
Benefits
- Provides long-lasting relief from acidity and heartburn
- Helps heal acid-related damage to the stomach and esophagus
- Improves digestion and gastric motility
- Reduces nausea, bloating, and abdominal discomfort
- Sustained-release formulation offers prolonged symptom control
Dosage
Use as directed by the physician. Usually taken before meals, preferably before breakfast. Swallow the capsule whole without crushing or chewing the pellets.
Possible Side Effects
- Dry mouth
- Headache
- Abdominal pain
- Diarrhea or constipation
- Dizziness
- Flatulence
- Nausea
Most side effects are mild and temporary.
Precautions
- Use cautiously in patients with liver, kidney, or heart disorders.
- Long-term use should be under medical supervision.
- Inform the doctor about all ongoing medications before use.
- Avoid alcohol, smoking, and spicy foods that may aggravate acidity.
- Not recommended during pregnancy or breastfeeding unless prescribed by a healthcare professional.
